From Melanoma to Skin Aging: The Impact of DCT and TYRP۱ in Melanogenesis

Melanoma is responsible for over ۹۰% of skin cancer deaths. Skin color and cumulative UVexposure are both known risk factors for skin cancer as well as skin aging, which is not only aphysiologic phenomenon but also a health risk, resulting in increased incidence of infection and skincancers [۱]. This study aims to pinpoint essential genes that contribute significantly to Melanomadevelopment and skin aging. The raw microarray data of GSE۳۵۳۸۸, including eight samples ofExpression data from normal melanocytes and melanoma cells, were obtained from the GeneExpression Omnibus (GEO) database. These data were based on the GPL۵۷۰ platform and werecontributed by Xiao D et al. [۲]. First, two groups were defined for analysis using GEO۲R, and a list ofgenes was obtained; after that, we filtered out a group of genes based on their adjusted P-value < ۰.۰۵and — logFC >-۲; second, we constructed the protein-protein interaction network from the STRINGdatabase to identify hub genes. Finally, two genes were chosen according to their excellent betweennesscentrality and Tau specificity score (from the HUMAN PROTEIN ATLAS database): DCT and TYRP۱.which, Based on the REACTOME database, are in the same signaling pathway leading to melaninbiosynthesis and have been linked to various skin aging phenotypes. In conclusion, skin aging and skincancer might be associated; they could coexist in one genetically predisposed individual but might eveninfluence each other [۳]. Therefore, targeting these genes can be a potential therapeutic strategy for skinphenotypes.

کلیدواژه ها:

Melanogenesis ، Skin Pigmentation ، Melanoma ، Skin Cancer ، Skin Aging