Elution Properties and Antibacterial Activity of Vancomycin- LoadedAcrylic Bone Cements

Antibiotic-loaded acrylic bone cements are regularly used in the treatment of prosthetic jointinfections. In this work, the effect of drug contents on in vitro elution profiles and antimicrobialproperties against Staphylococcus aureus of cylindrical shape bone cements were studied.Poly(methyl methacrylate) (PMMA)-based bone cements were prepared with different contents (۱, ۴and ۷ (% w/w)) of vancomycin (Vanco) as antibacterial drugs. The Vanco elution profiles wereinfluenced by the composition and wettability of the cement surface. It was found that the amount ofreleased Vanco from sample containing ۷% drug with higher wettability was increased by about ۶times compared to the ۱% loaded ones after ۲۱ days.

کلیدواژه ها:

Medicine and Healthcare ، Bone Cement ، Vancomycin ، Elution Profiles.