Evaluation of coagulation behavior of methylated collagen as an potentialcollagen-based hemostate

In the present study, the coagulation properties of methylated collagen (MCH) was investigated.The methylation process was carried out on collagen type I and characterized using ourierTransform Infrared Spectroscopy (FT-IR). After methylation, the Amid II groups approximatelydisappeared in FTIR spectra, showing that the methyl groups are bond to COO-. Plateletaggregation test showed that methylated collagen hemostate (MCH) caused the coagulation after۲۰۶±۱۳ seconds, the value of which was ۲۶۳±۲۳ second for commercial hemostate (glatin-basedhemostate). The field emision scanning electron microscopy (FESEM) images showed that theplatelets migrated towards the MCH. The study demonstrated the potential of collagen-basedbiomaterials for hemostatic applications.

کلیدواژه ها:

Bio-polymers ، Collagen-based hemostate ، methylation ، coagulation