Enzymatically-gellable modified starch-gelatin hydrogels for tissueengineering applications

Biomaterials play a key role for tissue engineering in most approaches. New biomaterials could becomposed of various components. The hydrogel forms of biomaterials seem to be one of the mostpromising application for biomedical purposes. In this study, gelatin-based hydrogels with modifiedstarch containing lysine group (CMS-L) in the presence of microbial trans-glutaminase (mTG) wasfabricated and characterized by the physical, mechanical as well as animal cell culture tests. Resultsshowed that the addition of CMS-L to gelatin-based hydrogels increased swelling and degradationwhile decresaed hydrogel mechanical strength. The fibroblastic cells could proliferate well in thefabricated hydrogels ۵ days. The study demonstrates the potential of CMS-L- Gel-mTG hydrogelsfor medical and tissue engineering application.

کلیدواژه ها:

Enzymatically-gellable hydrogel ، Gelatin ، Modified starch