Mesoporous Silica Coated Polydopamine Functionalized PolyphenolicNanosheet for Synergistic Chemo-Photothermal Therapy

Cancer is among the leading causes of death worldwide. Novel therapeutic strategies, such ascombination therapy into a single nanoplatform, have shown great promise for synergistic tumortreatment. Here, a new, cost-effective approach is introduced for producing photothermal materialssourced from the polyphenolic fraction of propolis (PFP). The process involves pyrolyzing PFP underneutral conditions, producing ۲D PFP-based nanosheets (PFPNS) sized between ۵۰-۱۰۰ nm witheffective photothermal characteristics. Subsequently, a multi-layered nanohybrid structure featuringPFPNS, polydopamine (PDA), mesoporous silica (MS), and polyethyleneimine (PEI) layers(PFPNS@PDA@MS-PEI), is crafted as versatile drug delivery platform. Specifically, the anticancerdrug doxorubicin (DOX) is loaded onto the nanohybrid (PFPNS@PDA@MS(DOX)-PEI) fortargeted delivery to cancer cells. Each layer of the nanohybrid serves a distinct function, augmentingeffectiveness. The NIR-responsive PFPNS@PDA component expedites drug release and induceshyperthermic effects on cancer cells upon NIR exposure. The MS structure enables a high drugloading capacity (~۸۳.۳%), while the pH-responsive PEI layer enhances cellular uptake and promotesdrug release within the acidic tumor microenvironment. The concurrent use of NIR irradiation andchemotherapy yields a synergistic effect, resulting in the eradication of ۶۷% of MCF-۷ breast cancercells.

کلیدواژه ها:

Polymers in medicine ، nanohybrid ، polyphenol nanosheet ، photo-chemotherapy