Synthesis of PLGA-Curcumin Nanoparticles via Nanoprecipitation Methodfor Targeted Drug Delivery Systems

Controlled drug release is currently recognized as a significant area of study within medical research.This is attributed to its array of clinical benefits, which surpass those of conventional techniques,notably in terms of its effectiveness and the precision with which medications can be delivered. Oneof the commonly used techniques to benefit from controlled release is the encapsulation of an activeagent in a polymeric matrix through nanoprecipitation. The nanoprecipitation method is a techniqueused to create nanoparticles for drug delivery systems. It's particularly noted for its simplicity,efficiency, and versatility. This study involved the preparation of drug-polymer particles usingpolylactic-co-glycolic acid (PLGA), a polymer known for its excellent biocompatibility andbiodegradability, and curcumin (CUR), chosen for its anti-cancer qualities despite its low watersolubility. At the outset, the encapsulated particles were prepared via nanoprecipitation.Subsequently, the sample was subjected to a variety of assessments. The findings from the FourierTransform Infrared Spectroscopy (FTIR) indicated that curcumin was successfully incorporated intothe polymer matrix. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy(TEM) were employed to prove the particles’ sphericity and uniformity of drug distribution withinthe polymeric matrix. Ultimately, the UV Spectroscopy technique was utilized to reach the in vitroand biphasic release profile of curcumin from the particles which is crucial for a controlled drugrelease in body.

کلیدواژه ها:

Controlled Drug Release ، Nanoprecipitation ، PLGA ، Curcumin