Wet Chemical Synthesis of Sodium Sulfonated Polybutylene Fumarate-co-Acrylic Acid/nano hydroxyapatite Nanocomposite as Bone Scaffold

A cross-linking agent with hydrophilic sulfonate groups was used to synthesize Sodium SulfonatedPolybutylene Fumarate-co-Acrylic Acid hydrogel. Subsequently, the chemical immersion methodwas employed to produce hydroxyapatite nanoparticles in situ and form the nanocomposite. SEM,weight gain and biocompatibility tests were used to characterize the nanocomposite. The resultsshowed that due to the presence of hydrophilic groups in the hydrogel structure and the formation ofchelates between ions in the simulated body fluid and hydrogel agents, nanoparticles formed withinthe structure, allowing the production of nanocomposites with high percentages of nanoparticles. TheMTT assay and cell attachment results indicate that the scaffolds are non-cytotoxic

کلیدواژه ها:

Hydrogel ، sulfonation ، wet chemical deposition ، scaffold