Dual cross-linked Polyhydroxy urethane tannic acid with Photothermal andantioxidant properties as wound dressing material

Chronic wounds pose significant healthcare challenges due to infection and inflammation. This studyaimed to develop an improved wound dressing with antibacterial, antioxidant, and mechanicalproperties. We synthesized a crosslinked polyhydroxyurethane (PHU) with intact secondary aminesfor functionalization. Tannic acid (TA), a natural polyphenol, was incorporated as a crosslinker viaSchiff-base and Michael addition reactions, adding photothermal and antioxidant functionalities.Gelatin was included to enhance biocompatibility and exudate management. The dressings exhibitedtensile strength up to ۴ MPa and significant temperature rise upon NIR light exposure, influenced byTA content. All TA-containing dressings showed free radical scavenging activity.

کلیدواژه ها:

Polymers in Medicine and Healthcare ، Wound dressing ، Photothermal ، Polyhydroxyurethane ، Tannic Acid