Preparation of anticancer drug carrier particles based on ۲-hydroxyethylmethacrylate

In this work, ۲-hydroxyethyl methacrylate (HEMA) was modified by ibuprofen and diclofenac drugsto synthesize Ibuprofen-HEMA and Diclofenac-HEMA. Then, poly(ibuprofen-HEMA-HEMA) orPIHH, poly(diclofenac-HEMA-HEMA) or PDHH and poly(۲-hydroxyethyl methacrylate) orPHEMA were synthesized by precipitation-distillation polymerization method. After that,doxorubicin drug was loaded into the prepared particles and the drug release behavior wasinvestigated for all the particles at two different pHs of ۷.۴ and ۵.۳.

کلیدواژه ها:

Poly(۲-hydroxyethyl methacrylate) ، Ibuprofen ، Diclofenac ، Drug toxicity ، Doxorubicin.