Synthesis and characterization of double cross-linked PolyhydroxyurethaneWound Dressings based on Diels-Alder click reaction and covalent bonds

This work aimed to prepare wound dressing membranes based on non-isocyanate polyurethane withdesirable features such as appropriate mechanical properties, effective antibacterial activity, and theability to maintain a moist environment over the wounded area to accelerate the wound healingprocess. Firstly, a polyhydroxyurethane (PHU) prepolymer with secondary amine groups wasprepared through ring-opening reactions of poly(ethylene glycol) bis cyclic carbonate withtriethylenetetramine. This PHU was then functionalized with furfuryl glycidyl ether to obtain furanfunctionalizedpolyhydroxyurethane (FPHU). The membrane was prepared by adding itaconic acidbasedepoxy resin as a crosslinking agent to FPHU and formation dynamic bonds through Diels-alderreaction. Finally, the final wound dressing was prepared by modifying the membrane withpoly(hexamethylene guanidinium hydrochloride). The prepared dressing membranes exhibited goodtensile strength in both dry and hydrated states. The fluid handling capacity of the membranes wassuitable for treating wounds with "light" to "moderate" exudate levels. Furthermore, the dressingshowed effective antibacterial activity against Staphylococcus aureus and Escherichia coli.

کلیدواژه ها:

Polymers in Medicine and Healthcare ، Wound dressing ، Diels-alder ، Poly(hexamethylene guanidinium hydrochloride) ، Polyhydroxyurethane