Copper Phthalocyanine Loaded Poly (lactic acid) Nanoparticles by DoubleEmulsion Methodology for Photothermal Therapy

Nanoparticles were synthesized using the solvent emulsion evaporation method (SEEM) to encapsulatecopper phthalocyanine (CuPc) as a contrast agent in photothermal therapy into poly (lactic acid) (PLA). Thedesirable physicochemical characteristics include particle sizes with an average of ۵۲۰.۹ nm, uniformlydistributed within a narrow range (PDI of ۰.۲۵), drug loading (۱۷۴.۸۱ μg. mg-۱), and the highestencapsulation efficiency (۹۱.۷%). The nanoparticle formulation exhibits a negative zeta potential value (-۲۸.۱ mV), explaining its colloidal stability. Also, the FTIR spectra confirmed the successful encapsulationof CuPc within the PLA nanoparticles. These findings suggest that PLA-CuPc nanoparticles are promisingphotothermal agents that could enhance the efficacy of photothermal therapy (PTT).

کلیدواژه ها:

Photothermal therapy ، CuPc ، polymeric nanoparticles ، encapsulation ، SEEM