Synthesis Novel Light-Responsive Polymeric Surfactant for Preparing PLGANanoparticles

The controlled release of therapeutic substances is a prominent strategy in medical sciences due to itsmultiple therapeutic effects. This study focuses on encapsulating pharmaceuticals in polymerparticles employing poly(lactic-co-glycolic acid), PLGA, as the polymeric matrix bynanopercipitatoin method. Given the importance of emulsifiers in this procedure, Light-sensitiveemulsifier was synthesized using the reversible addition fragmentation chain transfer (RAFT)polymerization method to produce particles with the appropriate characteristics. The characteristicsof particles derived from commercial (Pluronic P۱۰۱) and synthesized emulsifiers were investigated.The findings reveal that the morphology of the final particles generated by synthetic emulsifiers isspherical and more homogeneous. Furthermore, the light sensitivity of synthetic emulsifiers allowsfor the monitoring of particle formation. Because of the characteristics indicated above, it is logicaland prudent to use synthetic emulsifiers for producing PLGA-based drug carrier particles.

کلیدواژه ها:

Nanopercipitaion ، PLGA ، RAFT polymerization ، Light-responsive ، Surfactant