Dual pH-Enzyme Responsive Host-Guest Micelles for Targeted SenescentCell Therapy

This study presents the development of a novel dual-responsive supramolecular micellar system fortargeted drug delivery to senescent cells. The micelles comprise a β-cyclodextrin-star-polyethyleneglycol (β-CD-star-PEG) host and a benzimidazole-polycaprolactone (BM-PCL-BM) guest, formingstable inclusion complexes. The system exhibits pH and β-galactosidase responsiveness, enablingcontrolled drug release in senescent cell environments. Characterization by ۱H NMR and fluorescencespectroscopy confirmed successful assembly and host-guest interactions, while UV-vis turbiditymeasurements validated the system's responsiveness. This innovative approach offers promisingpotential for enhancing the efficacy of therapies targeting senescence-related disorders.

کلیدواژه ها:

Smart polymer ، Host-Guest inclusion complex ، pH responsive