Synthesis and Characterization of Hyaluronic-based AmphiphilicSelf-assembling Biopolymeric Nanoparticles

Nanoparticles formed through the self-assembly of amphiphilic polymers, also referred to aspolymeric micelles, have promising applications as delivery systems for hydrophobic drugs. Thispaper discusses the synthesis and characterization of an amphiphilic biopolymer comprised ofhyaluronic acid as the hydrophilic segment and lauric acid as the hydrophobic segment, as well asthe preparation of micelles from this polymer. The synthesized biopolymer was characterized using۱HNMR and FTIR spectroscopy, while the nanoparticles were characterized using DLS and FESEM.The prepared micelles' mean diameter was ۶۹ nm, with a narrow size distribution (PDI = ۰.۰۲) andcritical micelle concentration (CMC) of ۱۹.۳ μg/ml.

کلیدواژه ها:

Polymers in Healthcare and Medicine ، Polymer Synthesis and Characterization ، Selfassembly ، Polymeric Micelle ، Nanoparticles.