The Effect of Heparin Grafting on Surface Modification andHemocompatibility of Polylactic Acid

The risk of clot formation in blood_contacting devices is a significant concern. Therefore,development of biomaterials with improved hemocompatibility is necessary. Altering surfaceproperties is an effective strategy to improve the hemocompatibility. Poly(lactide)(PLA) is abiopolymer, biodegradable and biocompatible that used in many biomedical devices, however PLAhas a relatively hydrophobic, neutral surface and with poor functional groups. In this work, weimproved the hemocompatibility of PLA by using heparin. We used the chemical processing methodfor this, first functionalized the PLA surface by optimizing the conditions of the aminolysis methodsubsequently improved its applications with grafting heparin via a coupling agent and so on. Heparinis a polyanion, hydrophilic polysaccharide that has anticoagulation properties. Then thehemocompatibility and surface morphology of the samples were evaluated using ATR_FTIR, SEMand CBC assay. Finally, the results showed that the hemocompatibility of heparinized PLA sampleswere improved.

کلیدواژه ها:

Biopolymer ، Polylactic Acid ، Heparin ، Aminolysis ، Hemocompatibility