Synthesis and Characterization of Redox-Sensitive Polymeric Nanomicellesbased on Hyaluronic Acid and Alendronate

Polymeric micelles, owing to their amphiphilic nature, have been utilized as delivery systems forhydrophobic anticancer drugs. This article describes the synthesis of a self-assembled polymerthrough the grafting of hexadecanol onto hyaluronic acid branches, followed by the conjugatingalendronate, resulting in a polymer targeted to bone tissues. Embedding a disulfide bond into thepolymer structure has made the system sensitive to reducing agents. The chemical structure of thesynthesized polymers was evaluated and approved using FTIR and ۱HNMR. The mean diameter ofprepared nanomicelles was determined by DLS analysis, as ۱۱۴ nm with a narrow distribution size(PDI ۰.۰۱) and critical nanomicelle concentration (CMC) of ۱۳.۹۵ μg/ml. FESEM analysis confirmstheir spherical morphology

کلیدواژه ها:

Polymers in Healthcare and Medicine ، Redox-sensitive Nanomicelles ، Self-assembly ، Nanoparticles.