Synthesis and Characterization of PMMA-based Microbubbles withPerfluorohexane Core

This study provides polymerization of poly(methyl methacrylate) through reversible fragmentationchain polymerization and its application in the preparation of microbubbles. Fourier-transforminfrared spectroscopy and optical microscopy were used to examine the chemical structure of theresulting polymer and to observe the particles formed in the emulsion and microbubbles,respectively. The optical microscopy images showed uniform spherical particles without significantagglomeration. The perfluorohexane core of the microbubbles allowed the conversion of stimuliresponsivemicrodroplets into microbubbles after exposure to heat generated from the microscopelight. This phase transition resulted in a tenfold increase in particle diameter from the microdropletto the microbubble stage while maintaining spherical morphology. The developed systemdemonstrated the potential for application in drug delivery and medical imaging

کلیدواژه ها:

Microbubbels ، drug delivery ، perfluorohexane ، poly(methyl methacrylate)