Fabrication and investigation of physical and mechanical properties ofhydroxyapatite nanocomposite scaffold in bone tissue engineering

The aim of this research is to make a bone tissue engineering scaffold from Gelatin (Gel) in the presence ofCellulose nanocrystal (CNC) and Hydroxyapatite nanoparticles (n-HAP). The mechanical properties of allscaffolds were evaluated in both dry and wet conditions by compressive mechanical test. The compressivemodulus with increasing CNC increased to ۲۴ MPa in the wet state at ۹۰% strain and ۴۳ MPa in the dry stateat ۸۰% strain. By increasing n-HAP by (۲.۵, ۵ and ۱۰ %wt/wt) the compressive modulus in the wet state at۹۰% strain is ۱۹.۴, ۱۴.۹ and ۱۱.۱ respectively and in the dry state at ۸۰% strain respectively. ۴۴.۸, ۲۱.۴ and۲۰.۶ MPa decreased. The results showed that GCH(Gel/CNC/n-HAP) network scaffolds have the potentialto be used in bone tissue engineering

کلیدواژه ها:

Porous scaffold ، bone tissue engineering ، gelatin ، crystalline nanocellulose ، nanohydroxyapatite ، citric acid ، crosslinking