Synthesis and charecterization of pH-responsive hybrid hydrogels based onchitosan, acrylic acid and ۲-hydroxyethyl methacrylate

Hydrogels are a promising platform for drug delivery due to their ability to encapsulate, protect, andrelease therapeutic agents gradually. While pH-responsive hydrogels from natural polymers offerbiocompatibility and biodegradability, they lack mechanical strength. Combining natural andsynthetic polymers improves the drug delivery efficiency. In this study hybrid hydrogel based onchitosan, acrylic acid and ۲-hydroyethylmethacrylate were syntheized using free radicalpolymerization mechnaism. The hydrogels were characterized and the swelling ratio of the hydrogelsbased on different formulations were evaluated. The synthesized hybrid hydrogels will be utilized ascarriers for oral colon-targeted drug delievry.

کلیدواژه ها:

Polymer Synthesis ، Hydrogels ، Polymerization ، Chitosan ، Acrylic Acid ، Drug Delivery