۳D printing of silk fibroin/alginate/Montmorillonite scaffold for bone tissueregeneration

With the rapid advancement of technologies, bone tissue engineering (BTE) has become a promisingmethod for reconstructing large bone defects. Scaffolds, key components of tissue engineering, arecreated to mimic the functions of host tissue and offer an appropriate microenvironment for theproliferation and differentiation of host cells. ۳D printing is a new and growing technique to fabricatescaffolds with perfectly controlled and patient-specific structures for BTE. Silk Fibroin (SF) , becauseof its excellent mechanical properties and Alginate(Alg) , as a biocompatible and biodegradablepolymer,are widely used in BTE. In this study, we prepared Alg/SF scaffolds with varying ratios ofMMT by ۳D printing method and compared their printability. The best printability was observed in۴%w/v of MMT. The resault shows that this scaffold is positive in term of bone regeneration andMMT nanoclay can enhance the printability of the ink.

کلیدواژه ها:

Additive Manufacturing ، ۳D Printing inks ، Silk fibroin ، Alginate ، Bone TissueEngineering