Improving the Hemostatic Properties of an Injectable In-Situ Hydrogel byAmine-Functionalized POSS Salt

Injectable, in situ gelling hydrogels for hemostasis were developed based on natural polysaccharides,chitosan, and dextran. The hydrogels were formed through Schiff base reactions between the aminegroups of chitosan hydrochloride and the aldehyde groups of oxidized dextran, eliminating the needfor crosslinking agents. To enhance the hemostatic properties, amine-functionalized polyhedraloligomeric silsesquioxane (POSS) was incorporated into the hydrogel network. The inclusion ofPOSS significantly improved swelling capacity,porosity, gelation time, and clotting time,demonstrating the potential of these hydrogels as effective hemostatic agents

کلیدواژه ها:

Hemostatic Agents ، POSS ، Chitosan ، Dextran ، In-Situ ، Schiff Base