Na Alginate/PVP/HAp Composite Hydrogels as Nano-carriers for Bone infections

Treatment of chronic bone infections is a major orthopedic challenge. In this research, we developeda drug release system using two biocompatible and biodegradable polymers and biocompatibleceramic nanoparticles. Hydrogels of sodium alginate (SA) were blended with polyvinyl pyrrolidone(PVP) and mixed with hydroxyapatite (HAp) nanoparticles to create hydrogel nanocomposites in theform of microbeads as drug carriers. The effect of PVP and HAp nanoparticles in hydrogels on therelease rate of ciprofloxacin in phosphate-buffered saline at pH ۷.۴ (simulating the bodyenvironment) was investigated. To characterize the developed drug delivery systems, analysesincluding FT-IR, XRD, and SEM were conducted. Microspheres containing nanohydroxyapatiteshowed a stable drug release profile suitable for the treatment of bone infection with effectivebioactivity.

کلیدواژه ها:

Nano-composites ، Hydrogel ، Drug delivery system ، Bone infection