Blending of Polyethylene Glycols with Different Molecular Weights:Physical Properties and Ibuprofen Delivery

Polyethylene glycols (PEG) in different molecular weights are used as water-soluble carriers todeliver a long list of therapeutic agents to rectal mucosa. However, the necessary physical propertiesor drug delivery kinetics are rarely achieved using a single PEG with a definite average molecularweight and polydispersity index implying a certain need for blending. To this end, PEGs in differentmolecular weights (MW=۲۰۰۰-۱۰۰۰۰ g.mol-۱) were used in alone or as ۵۰:۵۰ dual blends toformulate ibuprofen (IBU) suppositories. Physical and drug delivery characteristics of the deviceswere investigated supporting that ۵۰:۵۰ blends of PEG ۲۰۰۰:۱۰۰۰۰ and PEG ۴۰۰۰:۱۰۰۰۰ presentedthe optimal physical properties and IBU release kinetics. According to the results, difference inmolecular weight of PEGs affect drug release kinetics only at early times, i.e. ۲۰ minutes

کلیدواژه ها:

Polymers in Medicine and Healthcare ، PEG ، Blend ، Ibuprofen ، Drug Delivery