Synthesis of stimuli-responsive nanocomposite based on modified-chitosanand grapahene oxide

Stimulus-responsive hydrogels have gained significant attention in biomedicine for theirhydrophilicity, biocompatibility, and three-dimensional structures. Drug delivery systems withnanomaterials less than ۲۰۰ nm have been widely used due to improved mechanical properties andincreased permeability and retention (EPR effect). By adding modified graphene nanosheets to thehydrogel composite, the mechanical properties is improved and, consequently, the drug released ismore controllable. Hydrogel based on modified-chitosan and graphene oxide was synthesized by freeradical polymerization mechanism. The dispersion of graphene oxide nanoparticles and thecharacterization of surface functional groups on the modified graphene nanosheets were analyzedusing XRD. Subsequently, notable enhancements in mechanical properties were observed within thecarrier matrix. Various analytical techniques, including FTIR, mechanical test and swelling studieswere utilized to investigate the physical and chemical properties of the delivery system

کلیدواژه ها:

medical ، Stimuli-Responsive Hydrogels ، Drug Delivery System ، Graphene Oxide