Nano-scale Interactions of Cellulose Nanofibers on Mammalian Cell Membranes

Cellulose nanofibers with distinguishable features, such as high biocompatibility and low toxicity along with suitable physical and biochemical characteristics, are proposed as a potential tool for drug delivery. In natural systems, these nanofibers aggregate into nano-cylindrical and nano-planar arrangements. For drug delivery systems, studying the interactions of the cell membrane with the designed carrier is crucial, because it demonstrates how cell membrane composition affects the cellular uptake of the drug. In this study, the interaction between the mammalian cell membranes and the nanocylinder cellulose structure was investigated using molecular modelling and molecular docking techniques. The results showed that cellulose nanocylinder arrangements tend to form stronger interactions with the lipidic acyl tails of the membrane phospholipids rather than the hydrophilic head groups of these phospholipids.

کلیدواژه ها:

Mammalian Cell Membrane ، Cellulose Nanofibers ، Cellulose Nanocylinder ، Molecular Docking