بیوپسی مایع و اهمیت آن در تشخیص زودهنگام سرطان پستان

فرخنده حسن نژاد; احمد فضیلت; کیوان مجیدزاده

بیوپسی مایع و اهمیت آن در تشخیص زودهنگام سرطان پستان

محل انتشار: فصلنامه بیماری های پستان، دوره: 17، شماره: 3

سال انتشار: 1403

نوع سند: مقاله ژورنالی

زبان: فارسی

مشاهده: 135

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https://civilica.com/doc/2101228

شناسه ملی سند علمی:

JR_IJBD-17-3_004

تاریخ نمایه سازی: 27 مهر 1403

چکیده مقاله:

مقدمه: غربالگری و تشخیص زودهنگام سرطان پستان سبب کاهش مرگ ومیر و بهبود کیفیت زندگی می گردد. در عین حال روش های مرسوم غربالگری همچون ماموگرافی می توانند نتایج مثبت کاذب و هزینه برای بیمار به همراه داشته باشند. بیوپسی مایع یک ابزار تشخیصی نوظهور است که نشانگرهای زیستی را در خون و سایر مایعات بدن تجزیه و تحلیل می کند تا اطلاعاتی در مورد ژنتیک تومور و پاسخ به درمان ارائه دهد. بیوپسی مایع را می توان به عنوان نمونه برداری از اجزای سلول های تومور که از تومور و/یا رسوبات متاستاتیک در خون، ادرار، مدفوع، بزاق و سایر مواد بیولوژیکی آزاد می شوند، تعریف کرد. چنین اجزایی شامل سلول های تومور در گردش (CTCs)، DNA تومور در گردش (ctDNA) یا RNA تومور در گردش (ctRNA)، پلاکت ها و اگزوزوم ها هستند. لذا هدف از این مطالعه مروری، نشان دادن نقش بیوپسی مایع در تشخیص زودهنگام سرطان پستان و پزشکی شخصی می باشد. روش بررسی: در این مطالعه مروری سیستماتیک، از طریق جست و جو و بررسی داده های مرتبط با بیوپسی مایع و بیومارکرهای تشخیص زودهنگام سرطان پستان منتشر شده در پایگاه های داده معتبر بین المللی نظیر Scopus، PubMed، Web of Science و Google Scholar بین سال های ۲۰۱۸ تا ۲۰۲۴ تلاش شده تا جدیدترین نوآوری ها و پیشرفت های حوزه تشخیص و پزشکی شخصی بررسی گردد. یافته ها: با بررسی مطالعات و مقالات منتشر شده در این زمینه مشخص شد که امروزه کاربرد بیومارکرهای موجود در بیوپسی مایع، نقش پررنگی در پزشکی دقیق و تشخیص زودهنگام سرطان پستان و دیگر سرطان ها ایفاء می کنند و بسیاری از آن ها تاییدیه های معتبر بین المللی نظیر FDA را نیز کسب کرده اند. از بیوپسی مایع و بیومارکرهای موجود در آن ها می توان با توجه به ارتباط آن ها با فنوتیپ های سرطان پستان در پزشکی شخصی استفاده کرد. نتیجه گیری: بیوپسی مایع پتانسیل تشخیص سرطان در مراحل اولیه، نظارت بر پیشرفت و عود تومور، و پیش بینی پاسخ بیمار به درمان را فراهم می کند. چندین مطالعه کاربرد بالینی آن را در غربالگری و تشخیص سرطان پستان در بیماران نشان داده اند و به طورکلی، بیومارکرهای موجود در بیوپسی مایع نویدبخش تشخیص زودهنگام سرطان پستان و کاهش قابل توجه مرگ ومیر ناشی از این سرطان در آینده ای نزدیک خواهند بود.

کلیدواژه ها:

Breast cancer ، Early detection ، Liquid biopsy ، Precision medicine ، Screening ، سرطان پستان ، بیوپسی مایع ، تشخیص زود هنگام ، پزشکی دقیق ، غربالگری

نویسندگان

فرخنده حسن نژاد

Department of Genetics, Breast Cancer Research Center, ACECR, Motamed Cancer Institute, Tehran, Iran

احمد فضیلت

Department of Genetics, Breast Cancer Research Center, ACECR, Motamed Cancer Institute, Tehran, Iran

کیوان مجیدزاده

Department of Genetics, Breast Cancer Research Center, ACECR, Motamed Cancer Institute, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :

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Yang, Y., et al., Elevation of serum CEA and CA۱۵‑۳ ...
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Martinez-Dominguez, M.V., et al., Current technologies for RNA-directed liquid diagnostics. ...
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Sung, H., et al., Global cancer statistics ۲۰۲۰: GLOBOCAN estimates ...
Bray, F., et al., Global cancer statistics ۲۰۱۸: GLOBOCAN estimates ...
Shah, S.C., et al., Cancer control in low-and middle-income countries: ...
Pramesh, C., et al., Priorities for cancer research in low-and ...
Arnold, M., et al., Progress in cancer survival, mortality, and ...
Crosby, D., et al., Early detection of cancer. Science, ۲۰۲۲. ...
Connal, S., et al., Liquid biopsies: the future of cancer ...
Klein, E.A., et al., Clinical validation of a targeted methylation-based ...
Campos-Carrillo, A., et al., Circulating tumor DNA as an early ...
Chen, D., et al., Liquid biopsy applications in the clinic. ...
De Rubis, G., S.R. Krishnan, and M. Bebawy, Liquid biopsies ...
Chen, M. and H. Zhao, Next-generation sequencing in liquid biopsy: ...
IJzerman, M.J., et al., Towards routine implementation of liquid biopsies ...
Wu, T.-M., et al., Power and promise of next-generation sequencing ...
Zubor, P., et al., Why the gold standard approach by ...
Tay, T.K.Y. and P.H. Tan, Liquid biopsy in breast cancer: ...
Cohen, J.D., et al., Detection and localization of surgically resectable ...
Hirschfeld, M., et al., Urinary Exosomal MicroRNAs as Potential Non-invasive ...
Jakabova, A., et al., Characterization of circulating tumor cells in ...
Zhong, G., et al., Determination of Serum Exosomal H۱۹ as ...
Chanteloup, G., et al., Monitoring HSP۷۰ exosomes in cancer patients' ...
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Darga, E.P., et al., PD-L۱ expression on circulating tumor cells ...
López-Jornet, P., et al., Salivary biomarkers in breast cancer: a ...
Kure, S., et al., A prediction model using ۲-propanol and ...
Kamel, A.M., et al., Plasma DNA integrity index as a ...
Lee, Y., S. El Andaloussi, and M.J. Wood, Exosomes and ...
Cohen, J.D., et al., Detection and localization of surgically resectable ...
Beaver, J.A., et al., Detection of cancer DNA in plasma ...
Kruspe, S., et al., Rapid and sensitive detection of breast ...
Shimomura, A., et al., Novel combination of serum microRNA for ...
Erbes, T., et al., Feasibility of urinary microRNA detection in ...
Hirschfeld, M., et al., Urinary exosomal microRNAs as potential non-invasive ...
Souza, K.C., et al., Identification of cell-free circulating microRNAs for ...
Zhong, G., et al., Determination of serum exosomal H۱۹ as ...
Zhao, R., et al., Exosomal long noncoding RNA HOTTIP as ...
Best, M.G., et al., RNA-Seq of tumor-educated platelets enables blood-based ...
Zhang, L., et al., Discovery and preclinical validation of salivary ...
López-Jornet, P., et al., Salivary biomarkers in breast cancer: a ...
Lin, D., et al., Circulating tumor cells: Biology and clinical ...
Harouaka, R., et al., Circulating tumor cells: advances in isolation ...
Mohan, S., F. Chemi, and G. Brady, Challenges and unanswered ...
Pierga, J.-Y., et al., High independent prognostic and predictive value ...
Horimoto, Y., et al., Analysis of circulating tumour cell and ...
Brisotto, G., et al., Dysmetabolic circulating tumor cells are prognostic ...
Jakabova, A., et al., Characterization of circulating tumor cells in ...
Papadaki, M.A., et al., Clinical relevance of immune checkpoints on ...
Papadaki, M.A., et al., TLR۴ and pSTAT۳ Expression on Circulating ...
Lee, C.-H., et al., Baseline circulating stem-like cells predict survival ...
Chen, Z., et al., Monitoring treatment efficacy and resistance in ...
Raimondi, L., et al., Assessment of resistance mechanisms and clinical ...
Wan, J.C., et al., Liquid biopsies come of age: towards ...
Moore, L.D., T. Le, and G. Fan, DNA methylation and ...
Li, Y. and T.O. Tollefsbol, DNA methylation detection: bisulfite genomic ...
Chin, Y.M., et al., Serial circulating tumor DNA monitoring of ...
Wang, Y., et al., Genetic landscape of breast cancer and ...
Pantel, K. and C. Alix-Panabières, Liquid biopsy and minimal residual ...
Gerratana, L., et al., Longitudinal dynamics of circulating tumor cells ...
Yan, Y.-y., et al., Cell-free DNA: hope and potential application ...
Adashek, J.J., F. Janku, and R. Kurzrock, Signed in blood: ...
Singer, B.D., A practical guide to the measurement and analysis ...
Ramirez-Garrastacho, M., et al., Extracellular vesicles as a source of ...
Doyle, L.M. and M.Z. Wang, Overview of extracellular vesicles, their ...
Sandfeld-Paulsen, B., et al., Exosomal proteins as prognostic biomarkers in ...
Xie, C., et al., The role of extracellular vesicles from ...
Landegren, U. and M. Hammond, Cancer diagnostics based on plasma ...
Ding, Z., et al., Proteomics technologies for cancer liquid biopsies. ...
Yang, Y., et al., Elevation of serum CEA and CA۱۵‑۳ ...
Laessig, D., et al., Importance of CEA and CA ۱۵-۳ ...
Martinez-Dominguez, M.V., et al., Current technologies for RNA-directed liquid diagnostics. ...
Drokow, E.K., et al., Circulating microRNA as diagnostic biomarkers for ...
Shivapurkar, N., et al., Circulating microRNAs in patients with hormone ...
Griñán‐Lisón, C., et al., miRNAs as radio‐response biomarkers for breast ...
Salvador-Coloma, C., et al., Immunosuppressive profiles in liquid biopsy at ...
Xiao, R., et al., Tumor-educated platelets as a promising biomarker ...
GJG, S. and T. Wurdinger, Tumor-educated platelets. Blood, ۲۰۱۹. ۱۳۳(۲۲): ...
Sol, N., et al., Tumor-educated platelet RNA for the detection ...
Ergin, S., N. Kherad, and M. Alagoz, RNA sequencing and ...
Gerratana, L., et al., Understanding the organ tropism of metastatic ...

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