Curcumin Ameliorates Depression, and Anxiety in Patients with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blinded Placebo-Controlled Trial

Background & Objective:  Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are gynecological conditions that are associated with psychological and mood disorders. This study assessed the effects of curcumin, a natural polyphenol, on depression, anxiety, stress and quality of life (QL) in woman with PMS and PD.  Materials & Methods: The study was undertaken in ۱۲۸ women who were randomised to treatment with either curcumin (n=۶۴) or placebo (n=۶۴) groups. Each subject received one capsules (۵۰۰ mg of curcuminoids plus ۵ mg piperine, or a placebo, plus ۵ mg piperine) daily, for ۳ successive menstrual cycles. Psychological status and QL were assessed using Depression, Anxiety, Stress Scales-۲۱ (DASS-۲۱) and the Short Form-۱۲ (SF-۱۲) questionnaires respectively.  Results: Overall scores as well as the mental health domain of the SF-۱۲ improved significantly after curcumin supplementation (P<۰.۰۵). In addition, curcumin decreased significantly (P<۰.۰۵) all of the DASS-۲۱ domains (depression, anxiety and stress). Significant differences were also found between the two groups for the DASS-۲۱ domains, SF-۱۲ mental health (total) and overall scores (P<۰.۰۵). Conclusion: Curcuminoids may be useful as a natural, widely accessible therapeutic option for the management of the psychological impact of PMS and PD, and improve the QL of women with these conditions.

کلیدواژه ها:

Curcumin ، Menstruation ، Personality ، Gynecology ، Anxiety