The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity

Background: This is a descriptive cross-sectional study to investigate the severity of acute baclofen poisoning and length of hospital stay (LOS) Methods: The documents of cases with baclofen poisoning diagnosis; Baclofen alone intoxication (BAI) and multidrug intoxication (MDI) (March ۲۰۱۵-۲۰۱۹) were evaluated. Clinical and paraclinical findings, LOS, APACHE, and Poison Severity Scores (PSS) were extracted. Results: From ۴۶ collected cases ۱۰ cases were BAI and all of them were women. The adult cases who attempted suicide were younger (۲۶.۰۹±۹.۶۲ years) than those accidentally poisoned (۵۸.۲۹±۲۲.۰۶ years) (PV=۰.۰۰۸). Two BAI (۲۰%) and one MDI (۲.۷%) were apnotic. None of BAI had hypotension, hypertension, bradycardia, or tachycardia. Past medical history of depression has no statistically significant effect on the clinical manifestation. There were correlations between adult diastolic and mean arterial blood pressures with baclofen ingested dose and renal function test results. MDI and BAI had similar ingested baclofen doses (۱۵۲.۶۳±۶۷.۰ and ۱۳۰±۹۰.۳ mg). All BAI had GCS<۱۰. The mean of the calculated APACHE score was higher in BAI (۱۵.۴۳±۳.۲) than in MDI (۸.۸±۷.۸) groups (PV<۰.۰۵). APACHE score positively correlated with the LOS of BAI (R۲=۰.۸۳۰, b=۰.۲۸۷ CI=۰.۱۷۵-۰.۴۲۰; PV=۰.۰۰۱). APACHE score did not correlate with the estimated baclofen ingested dose. There is a positive linear correlation between PSS and APACHE score of BAI patients, (R۲=۰.۴۹۹, PV=۰.۰۳۳, B=۵.۰۰±۱.۸۹, PV=۰.۰۳۳, CI=۰.۵۲-۹.۴۷۹). However, there was no correlation between PSS of BAI cases and LOS (PV=۰.۲۴).Conclusion: The APACHE score had a positive correlation with the LOS.

کلیدواژه ها:

Poisoning ، Baclofen ، Muscle Relaxants ، APACHE ، Treatment outcome