The Implication of Chuang's Prognostic Scale in Metastatic Gastric Cancer

Background: Patients with metastatic gastric cancer (mGC) endure a significant symptom burden following subsequent lines of therapy. Accurate survival estimation is crucial for healthcare professionals and patients to make informed decisions regarding therapy options. This study evaluates Chuang's Prognostic Scale (CPS) for predicting survival in mGC patients after receiving at least two lines of palliative systemic therapy (PST).Method: This prospective study involved ۲۰۲ patients with mGC. The CPS includes eight categories: cognitive impairment, performance status, weight loss, tiredness, edema, and ascites, with a scoring range from ۰ to ۸.۵. A higher score indicates a poorer prognosis.Results: After a median follow-up period of ۳.۳۵ months, the median CPS value was ۴.۲. ۹۹ patients had a CPS < ۴.۲, with a median overall survival (mOS) of ۵.۸۶ months, while ۱۰۳ patients with a CPS ≥ ۴.۲ had an mOS of ۳.۹۶ months (P < ۰.۰۰۱). According to the receiver-operating curve, the cut-off value for CPS was ≤ ۴.۷, with a disease prevalence of ۷۶.۷% and an area under the curve of ۰.۹۴۹ (P < ۰.۰۰۰۱). The sensitivity was ۸۲.۶%, specificity was ۹۷.۸۷%, positive predictive value was ۹۹.۲%, and negative predictive value was ۶۳%. Cox regression analysis revealed that CPS was statistically significantly associated with mOS (P < ۰.۰۰۱). Furthermore, CPS was statistically significantly correlated with metastases to the liver, lung, lymph nodes, and bone (P values were ۰.۰۳, ۰.۰۲, <۰.۰۰۱, and <۰.۰۰۱, respectively).Conclusion: CPS is a valuable and accessible tool that can assist in selecting appropriate therapy for patients with mGC after two lines of PST

کلیدواژه ها:

Stomach Neoplasms ، Chemotherapy ، Survival ، Chuang's Prognostic score