Investigating the Relationship between Vitamin D Status and Multiple Sclerosis; A Case-Control Study

Introduction: Multiple Sclerosis (MS) affects the central nervous system, causing significant impairments in movement and sensory functions. Genetic and environmental factors, including vitamin D deficiency, play crucial roles in MS susceptibility and severity. Methods: Ninety-six MS patients were examined, and divided into patient (n=۴۸) and control (n=۴۸) groups matched for age and gender. Various parameters like age, disease onset, vitamin D levels, hair color, sunlight exposure, and sunscreen use were analyzed. Disease severity was assessed using the Expanded Disability Status Scale (EDSS) scores. Results: Statistical analysis revealed significant differences in age, disease onset, serum vitamin D levels, hair color, and sunscreen use at ۴۰ years old between patient and control groups. However, no significant variances were found in gender, age, eye color, and vitamin D levels based on disease type or EDSS scores. Notably, no substantial correlation was established between vitamin D levels and disability severity in MS patients, potentially due to suboptimal vitamin D supplementation. Conclusion: Patients with MS exhibited significantly lower levels of vitamin D compared to the control group. No significant correlation was found between vitamin D levels and the severity of disability in MS patients. This lack of correlation could be attributed to the suboptimal administration of vitamin D in MS patients.

کلیدواژه ها:

multiple sclerosis ، vitamin D ، case-control