In Silico Identification of Novel ncRNAs with a potential Role in diagnosis of Cervical Cancer

Abstract: Cervical cancer is the second leading cause of cancer death in female of developing countries. The main types of cervical cancers are squamous cell carcinoma and adenocarcinoma. Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs play crucial roles in regulating the initiation and progression of various cancers.  Different types of non-coding RNAs are such as sniRNAs، circRNAs، piRNAs، microRNAs and lncRNAs. In this research the effective factors in the pathogenesis of cervical cancer and the data related to miRNAs associated with cervical cancer were retrieved from the global databases. The databases that were examined in this research include: miR۲Disease and HMDD. Considering the importance and prevalence of cervical cancer, drawing this network will help to understand the importance of its role in the development and progression of cervical cancer. Because miRNAs and lncRNAs have high potential as therapeutic agents and innovative biomarkers, they can lead us to promising biological targets about cervical cancer.

کلیدواژه ها:

Cervical cancer ، miRNAs ، miR۲D ، HMDD.