Characterization of Hemoglobin Variants in the Çukurova Region of Turkey: Prevalence and Clinical Implications

Background: Hemoglobinopathies, the most prevalent single-gene disorders worldwide, are projected to see an increase in prevalence in the future. This study aims to identify abnormal hemoglobin variants in the Çukurova region. Methods: Blood samples were collected at the Central Laboratory of Çukurova University Balcalı Hospital, and abnormal hemoglobin types were determined using hemoglobin electrophoresis, sickling, and ARMS methods. Results: The study identified ۱۱۵ cases of HbAS, ۶۰ cases of HbSS, ۳ cases of HbSC, ۲ cases of HbAC, and ۱ case of HbAE. The findings indicate that the carriage of sickle cell traits is highest in the Çukurova region. The objective is to reduce the number of affected births and mitigate the economic burden on the country by implementing screening programs in regions where hemoglobinopathy is endemic. Conclusion: The Çukurova Region's high prevalence of HbS and the common practice of consanguineous marriages increase the likelihood of babies being born with HbSS. New screening methods are urgently needed to accurately distinguish carriers from patients and rule out common conditions like iron deficiency anemia. The success of screening programs depends on the population's acceptance, which can be improved through awareness creation and effective genetic counseling post-diagnosis.

کلیدواژه ها:

Hemoglobin Variants ، Çukurova ، Prevalence ، Clinical Implications