Efficient synthesis of new triazolopyridine derivatives using povidone-iodine as a catalyst

A straightforward and efficient method for the synthesis of triazolopyridines and related heterocycles has been developed, employing a one-pot condensation reaction of [۱,۲,۴]triazolo[۴,۳-a]pyridine-۳-amine and benzil with various aldehydes, catalyzed by the environmentally friendly povidone-iodine (PVP-I). This two-step reaction protocol is suitable for a broad range of aromatic and aliphatic aldehydes and is easily scalable, providing a versatile and high-yielding synthetic route. Triazolopyridines are a significant class of fused-ring heterocycles, with important applications in medicinal chemistry and materials science.

کلیدواژه ها:

Multicomponent reaction (MCR) ، One-pot reaction ، Oxidative cyclization ، Povidone-iodine (PVP-I) ، Triazolopyridines