Drug Release of Moxifloxacin Via Functionalized Porous Sol-Gel γ-Alumina

سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 65

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شناسه ملی سند علمی:

NZEOLITE09_072

تاریخ نمایه سازی: 9 مهر 1403

چکیده مقاله:

By aminopropyl functionalization of gamma alumina, the pore diameter decreased from ۱۷ to ۱۶.۶ nm. Moxifloxacin hydrochloride which exhibits limited solubility in water, was loaded at a concentration of ۱۰% (w/w) onto functionalized sol-gel γ-alumina (Gam-Al-NH۲) using an impregnation process. In vitro tests were conducted in simulated body fluid (SBF). The concentration of released moxifloxacin was measured using a UV-Vis spectrophotometer and the calibration curve was created. The drug release from Gam-Al-NH۲-Mox was ۸۰.۱% after ۱۳۲۰ min. It can be concluded that synthesized alumina derivatives have promising prospects for future development [۱] (Fig. ۱).

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نویسندگان

Mojtaba Ghorbani

Department of Inorganic Chemistry, Faculty of chemistry, Chemistry &Chemical Engineering Research Center of Iran, Tehran, Iran

Aliakbar Tarlani

Department of Inorganic Chemistry, Faculty of chemistry, Chemistry &Chemical Engineering Research Center of Iran, Tehran, Iran