Fabrication of ZIF-67 Functionalized silica nanoparticles-covered graphene oxide nanohybrids modified carbon paste electrode as a highly sensitive electrochemical sensor for antipyretic drug

Paracetamol, (PAR) N-acetyl-p-aminophenol (also known as acetaminophen), is a readily available, over-the-counter antipyretic and analgesic compound. It is a safe and effective analgesic agent used to treat fevers of viral and bacterial origin [1] and for the relief of pain associated with migraine, backache, arthritis, and postoperative pain. The higher dose of PAR can lead to the accumulation of toxic metabolites which may cause hepatoxicity and nephrotoxicity [2]. Thus controlling the amount of PAR in pharmaceuticals is of great importance for the general public health. Here, we present a simple and sensitive PAR sensor that was developed based on the Co (II)-based metalorganic framework/ silica nanoparticles-covered graphene oxide nanohybrids (ZIF-67/SiO2/rGO) as a new electrode modification material used on the structure of working electrodes for the first time. The sensor presented an excellent electrocatalytic response towards PAR sensing. Structural characterizations using X-ray Diffraction (XRD) and Fourier Transform Infrared (FTIR) spectra were performed. Morphological characterizations using Scanning Electron Microscopy (SEM) were carried out. ZIF-67/SiO2/rGO/CPE modified electrode exhibited higher peak current than the bare CPE, with excellent electrocatalytic ability to oxidize PAR, with a high sensitivity of 0.1233 μAμM−1cm−2, low detection limit, broad linear range of 0.5 μM−640 μM, and high selectivity. The synergistic effects of the enhanced electrochemical activity of ZIF-67 along with the enhanced conductivity of SiO2/rGO led to the high electrocatalytic efficiency of these nanostructured composites. In addition, the modified electrode affirms good stability and reproducibility, making it simple, and cost-effective with high sensitivity and selectivity. The results confirmed that the designed electrochemical sensor could be successfully employed for real sample applications with highly sensitive iodide determination.

کلیدواژه های Fabrication of ZIF-67 Functionalized silica nanoparticles-covered graphene oxide nanohybrids modified carbon paste electrode as a highly sensitive electrochemical sensor for antipyretic drug:

Paracetamol ، Metal-organic frameworks ، Silica nanoparticles ، Graphene oxide ، Electrochemical sensor