Fabrication of Ultrastable Porous Covalent Organic Framework/metal organic framework Assembled graphene quantum dots for the Sensitive Detection of antineoplastic drug

Nowadays, numerous antitumor active drugs are extensively used in the treatment of cancers [۱]. ۵-Fluorouracil (۵-FU) is an antineoplastic agent that has been widely employed in cancer chemotherapy, mainly in the treatment of colorectal, pancreatic, stomachic and breast tumors [۲]. Several analytical techniques have been proposed for ۵-FU detection.Combination of multiple electroactive nanomaterials with excellent conductivity, plays critical roles in enhancing the analytical performance. Metal-Organic Frameworks/Covalent Organic Frameworks Hybrid (MOF-COF Hybrid) combine the advantages of both MOFs and COFs to create materials with enhanced properties and functionalities. To our current understanding, the utilization of Schiff base network-۱ (SNW-۱)/ Cu metal-organic frameworks (Cu-MOF)/ graphene quantum dot nanocomposites (SNW-۱/Cu-MOF/GQDs) in the detection of ۵-FU has not been documented, marking the initial exploration of their efficacy in ۵-FU analysis. In this work, the SNW-۱/Cu-MOF/GQDs modified glassy carbon electrode (GCE) as an innovative electrochemical sensor was investigated to determine the ۵-FU. The physico-chemical characterization of SNW-۱/Cu-MOF/GQDs was done using spectroscopic and electrochemical techniques. As a result, the proposed modified electrode exhibited higher peak current than the bare GCE, with excellent electrocatalytic ability to oxidize ۵-FU, due to its higher conductivity, catalytic effect and synergistic effects between SNW-۱, GQDs, and Cu-MOF. Under optimized condition, differential pulse voltammograms (DPV) demonstrate that the oxidation peak current was proportional to its concentration in the range of ۵×۱۰−۷ to ۲۵۰×۱۰−۶ M, with high sensitivity and low detection limit (۷×۱۰−۸ M). In addition, the modified electrode affirms good stability and reproducibility, making it simple, cost effective with high sensitivity and selectivity. Finally, the fabricated sensor system shows a high recovery range varying from ۹۷.۲ to ۹۸.۶% towards the real samples. The proposed electrochemical probe might be a promising alternative to the prevailing diagnostic tools for the detection of ۵-FU.

کلیدواژه ها:

metal organic framework ، Covalent Organic Frameworks ، sensor ، ۵-Fluorouracil