Investigating the Sedative Pharmacokinetic Effects of Pre-intubation Administration of Atropine alongside Succinylcholine and Fentanyl Compared to Atropine and Propofol in Infants with RDS

Background: The study aims to compare the pharmacokinetic effects of administeringatropine alongside succinylcholine and fentanyl versus atropine and propofol in sedatinginfants with respiratory distress syndrome (RDS) before intubation.Methods: It involves patient selection, drug administration, monitoring vital signs, bloodsampling, analytical techniques, data analysis, and ethical considerations. Succinylcholine wasgiven for all infants over ۳۴ weeks and at the physician's discretion for those under ۳۴ weeks.The minimum dose for atropine and fentanyl was ۰.۱ mg, for succinylcholine, it was ۲ mg/kgand for propofol, it was ۰.۱۲۵ to ۰.۳ mg/kg per minute.Results: Administration of fentanyl reduced parameters of respiratory distress, such as heartrate and respiratory rate, with no significant difference between different doses. A serumfentanyl concentration of ۰.۴-۰.۶ ng/mL produced adequate analgesia and sedation in neonates.Atropine also was used to counteract bradycardia, which can be a side effect of medicationslike Succinylcholine. Administering Atropine alongside Succinylcholine and Fentanyl maylead to better intubation conditions with fewer attempts, while Atropine and Propofolcombination may pose risks of hypotension.Conclusion: when sedating infants with RDS before intubation, the choice betweenadministering Atropine alongside Succinylcholine and Fentanyl versus Atropine and Propofolinvolves considerations of the drugs' effects on hemodynamics, duration of action, andpotential complications. The selection should be based on the specific clinical scenario andpatient characteristics to ensure safe and effective sedation during the intubation process.

کلیدواژه ها:

Sedation ، Pharmacokinetic Effects ، Atropine ، Succinylcholine ، Fentanyl ، Propofol ، RDS