Strategic Insights into Polymeric Scaffold Design for Optimal Tissue Mimicry and Regeneration

سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 120

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شناسه ملی سند علمی:

CHHE01_0813

تاریخ نمایه سازی: 4 مهر 1403

چکیده مقاله:

Polymeric scaffolds have evolved from mere carriers of cells and bioactive molecules to dynamic matrices that actively instruct cells and guide tissue formation step-by-step. Achieving this sophisticated functionality requires a thorough understanding of the chemistry and physicochemical properties of both the tissues being engineered and the materials used. Effective scaffold design involves meticulous characterizations that include external geometry, encompassing macrostructure, microstructure, and internal connectivity, which are crucial for defining overall architecture and functionality. Surface properties, such as surface energy, chemical composition, electrical charge, and topography, are pivotal in influencing cell adhesion and interactions. Porosity and pore size are vital for facilitating cell infiltration, nutrient diffusion, and waste removal. Adhesion and biocompatibility ensure the scaffold adheres well to biological tissues and supports cell viability and proliferation without adverse reactions. The degradation profile of the scaffold, including its rate and pattern of biological degradation, must match the tissue healing process. Mechanical competence, including attributes such as compressive and tensile strength, is essential to withstand physiological loads and integrate seamlessly with the body’s mechanical environment, thereby enhancing tissue regeneration and mimicking the natural extracellular matrix.

نویسندگان

Mehran Mahjour

Student Research Committee, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Omid Fakhraei

Department of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Hosein Rostamani

Student Research Committee, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran- Department of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Matin Bahramian

Student Research Committee, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran