Polymeric Frameworks in Medicine: Reshaping Reconstruction for Diverse Anatomical Challenges

This review explores recent advances and challenges in tissue engineering for neural, bone, muscle, and tendon/ligament regeneration. Key topics include Schwann cell-assisted nerve regeneration, nano-fiber scaffolds for bone reconstruction, electrical stimulation in muscle regeneration, and collagen-based scaffolds for tendon/ligament reconstruction. Novel approaches, such as the integration of nanostructured materials and the utilization of growth factors, offer promising avenues for enhancing bone regeneration and overcoming the limitations of traditional grafting methods. Polymeric materials, both natural and synthetic, play significant roles in tissue engineering scaffolds. Natural polymers offer biologically active properties, while synthetic polymers provide controlled degradation and mechanical stability. Combining these materials enhances scaffold properties, fostering tissue regeneration in diverse anatomical contexts. Various polymer combinations in engineering scaffolds for tissue regeneration, including ceramics and composites, are developed with biomimicry, enhancing cell growth and tissue regeneration through techniques like salt leaching and ۳D printing, aiming for simpler fabrication and optimized performance for widespread use in tissue engineering. The article underscores the importance of bridging the gap between theory and practical outcomes in tissue engineering research.

کلیدواژه ها:

Tissue engineering ، polymer ، scaffold ، bone reconstruction