Evaluation of Meropenem, Imipenem, Colistin, Teicoplanin and Voriconazole Use in Ayatollah Taleghani Hospital

Abstract: There is a concerning crisis about antibacterial resistance which can be accelerated by the overprescribingof antibiotics. This global Health challenge is associated with severe complications so medicalinterventions including the use of antimicrobial stewardship programs, active participation of clinicalpharmacist in healthcare and antibiotic prescription based on antimicrobial culture should be performed.This study assessed the reasonable use of ۵ antimicrobials in Ayatollah Taleghani hospital.Method: Cross-sectional prospective study was conducted in Taleghani Hospital, Tehran, Iran. Totally ۱۲۱ patientsfrom ۳ wards of Intensive Care Unit, General surgery and vascular surgery, with a variety of underlyingdiseases, entered the study during ۳ months of follow up.The information about frequency, duration oftreatment, indication and dose of five antimicrobials (Meropenem, Imipenem, Colistin, Teicoplanin, andVoriconazole) were obtained based on the information collected from Hospital Information System,called HIS.Results: In the Intensive care unit the most prevalent antibiotics were Meropenem, Imipenem (۸۸.۷۳%) andColistin (۱۱.۲۷%); in vascular surgery unit, Meropenem, Imipenem (۹۶.۶۷%) and Colistin (۳.۳۳%) havehigh rate of administration and finally in general surgery ward Meropenem, Imipenem (۸۸.۲۳%) andColistin (۱۱.۷۶%) were the most common type of antibiotics.antibiotic therapy was started for ۶۱.۱۶% patients based on empiric therapy, and microbiological cultureswere utilized only for ۳۸.۸۴% of the patients. Antibiograms were used for only ۴.۹۵% of patients.Conclusion: According to the collected data, many antibiotics prescriptions were not for therapeutic culture-basedreasons. This can be followed by the increasing rate of antibiotic resistance, so there is a demand formedical training in order to reduce the irrational medical prescription and use.Appropriate use of antibiotics could be promoted by the use of an Antibiotic Stewardship Program(ASP’s). Involving at least one clinical pharmacist or infectious disease pharmacist can play a vital rolefor this purpose.

کلیدواژه ها:

Antibiotic prescription ، Microbiological culture ، Antibiotic Stewardship Program ، Meropenem ، Imipenem ، Colistin