Transition Metal Complexes of New Schiff Base Ligand Derived from Boron-based Vanillin with Study of Some of Their Biological and Medical Applications

Synthesis of new Schiff base ligand [(Z)-۴-(((۱H-۱,۲,۴-triazol-۳-yl)imino)methyl)-۲-methoxyphenyl dihydrogen borate] (L) by reaction of boron derivative of vanillin ( ۴-formyl-۲-methoxyphenyl dihydrogen borate) with ۳-amino-۱,۲,۴-triazole was carried on in a ۱:۱ mole ratio. In addition, the complexes of metal Co(II), Ni(II), and Cu(II) were characterized. Each compound was characterized using spectroscopic techniques such as FT-IR, ۱H-NMR, and UV-Vis spectrometry. Furthermore, the following analytical techniques were employed: thermal analysis (TG), atomic absorption spectroscopy (AAS), elemental microanalysis (C.H.N), measurements of the melting point, chloride analysis, magnetic sensitivity testing, and molecular conductivity tests. All of the complexes exhibited non-electrolytic behavior and their indicated geometrical shapes were octahedral. All compounds exhibited paramagnetic magnetic characteristics. The synthesized compounds possessed a good efficiency as antimicrobial activity (anti-bacterial and anti-fungal) against Escherichia coli (Gram-negative), Staphylococcus aureus (Gram-positive), and Candida albicans. The synthesized compounds were assessed as an in vitro anti-cancer agent against human thyroid carcinoma (FTCI۳۳), the result showed that the copper complex was more effective compared to ligand and its other complexes.

کلیدواژه ها:

Schiff base ، ۴-formyl-۲-methoxyphenyl dihydrogen borate ، ۳-Amino-۱ ، ۲ ، ۴-triazole ، Transition metal complex