Mupirocin Ointment Effect on Polyposis Recurrence After Sinus Surgery

Introduction:Staphylococcus aureus is an identified pathogen involved in the recurrence of symptoms in patients with chronic rhinosinusitis with nasal polyps. We investigated the effectiveness of a topical ointment of mupirocin applied in the nasal vestibule in lessening symptom recurrence and improving the efficiency of functional endoscopic sinus surgery.Materials and Methods: Patients with chronic rhinosinusitis, nasal polyps, and a positive nostril culture for Staphylococcus aureus were included in a clinical trial. The right nostril was determined as the intervention group (applying mupirocin ointment) and the left as the control group (applying vitamin A ointment). Lund-Mackay radiological scores and Lund-Kennedy endoscopic scores were examined at the time of diagnosis and six months later.Results: Among ۶۰ patients with chronic rhinosinusitis with nasal polyps, ۹۱.۶% were positive for nostril Staphylococcus aureus. Comparing the average of the diagnostic radiological and endoscopic scores with the follow-up values in both groups indicated a significant improvement after surgery (P-value=۰.۰۰۱, ۰.۰۰۱). However, there was no significant difference in the radiological and endoscopic score improvements between the study and control groups (P-value > ۰.۵۶, ۰.۷۴).Conclusion: Nasal mupirocin administration following endoscopic sinus surgery cannot significantly prevent symptom recurrence in chronic rhinosinusitis with nasal polyps.

کلیدواژه ها:

Chronic Rhinosinusitis ، Nasal Polyps ، Mupirocin ، Staphylococcus aureus