Drug-free in vitro activation and autologous transplantation in infertile women with diminished ovarian reserve: An experimental pilot study

سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 52

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شناسه ملی سند علمی:

JR_IJRM-22-6_001

تاریخ نمایه سازی: 17 شهریور 1403

چکیده مقاله:

Background: Poor ovarian response and diminished ovarian reserves (DOR) significantly contribute to female infertility. Previous attempts have been made to enhance follicular growth and improve pregnancy outcomes in these participants. Objective: This study aimed to assess the efficacy of the in vitro drug-free activation technique of the ovarian reservation and in vitro fertilization stimulation cycle outcomes in DOR participants. Materials and Methods: This pilot phase study investigated the impact of in vitro activation (IVA) on ovarian reservation and in vitro fertilization outcome in ۱۰ infertile women with DOR from May to December ۲۰۲۳ at Taleghani Infertility Center, Tehran, Iran. Participants underwent general surgery and laparoscopy, involving the removal of a portion of one ovary, immediate transfer to the laboratory, dissection into small cubes, and subsequent re-implantation into the cases’s ovary. The primary outcomes, include the count of retrieved oocytes, the number of oocytes reaching metaphase, and the secondary outcomes were the quantity and the number of embryos transferred, implantation rate, and occurrence of clinical pregnancy. Results: The study revealed a significant increase in the antral follicle count before and after IVA (p = ۰.۰۳۳). Before IVA, the median estradiol level was ۹۳.۵ (۵۷.۰), which reduced to ۷۹.۰ (۳۵.۰) after IVA, indicating a statistically significant difference. On average, ۲.۳ (۰.۸) oocytes were retrieved, among which ۱.۵ (۰.۷) were metaphase II oocytes. The observed pregnancy rate among the ۲ cases was ۲۲.۲%. Conclusion: The current study suggests that IVA may positively impact follicular growth and pregnancy outcomes among women with DOR.

نویسندگان

Saghar Salehpour

Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mahsa Kazemi

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sedigheh Hosseini

Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Nazanin Hajizadeh

Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Bahareh Karimi

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hajar Abbasi

Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mitra Nemati

Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Samaneh Esmaeili

Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hasti Ziaee

School of Medicine, University of Central Lancashire, Preston, United Kingdom.

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