Thymol Blue Release from Dried Polyacrylamide Filmogenic Solution Coated on a Quartz Cell: One-shot Study

The release kinetics of a model drug-like molecule (Thymol blue, TB) from dried polyacrylamide (PAm) filmogenic solution plated on a quartz cuvette into an aqueous solution was examined spectrophotometrically by one-shot measurement. The system was manufactured using the filmogenic solution-casting technique. Formulation was made by ۲ ml of glycerol as a plasticizer. There is potential for using the produced film as a controlled drug delivery system. In order to investigate the dye release mechanism, kinetic release experiment was carried out immediately after the plated filmogenic solution converted to a film. Four mathematical models were applied to fit the experimental data. The Korsmeyer–Peppas kinetics model demonstrated the best correlation for the sample, and the release of TB can be regulated over a duration of one hour. The quasi-Fickian diffusion with n values of ۰.۲۰۰۲ controlled the kinetics of TB release. There is potential for using the filmogenic solution as a controlled drug delivery system.

کلیدواژه ها:

Release Mechanism ، model drug release ، Mathematical Modeling