Clinical characteristics and outcomes of band keratopathy: a ۱۰-year retrospective analysis

Abstract Background: Band keratopathy is a chronic, degenerative corneal disease resulting from gradual calcium deposition in the superficial cornea. Herein, we report the spectrum of causes, treatment outcomes, and recurrence rates of band keratopathy at a tertiary referral center throughout one decade. Methods: This retrospective study included patients with clinical diagnoses of band keratopathy who were treated with combined ethylenediaminetetraacetic acid (EDTA) and superficial keratectomy with or without amniotic membrane transplantation (AMT). Patient medical records were reviewed, and detailed demographic and ophthalmological data, such as baseline and last follow-up best-corrected distance visual acuity (BCDVA), ocular or medical comorbidities, type of intervention, postoperative follow-up duration, relevant complications, and recurrence were recorded. Results: A total of ۳۲ eyes of ۲۹ patients with ۳ (۱۰.۳%) bilateral and ۲۶ (۸۹.۷%) unilateral cases of treatment-requiring bank keratopathy were included. The mean (standard deviation [SD]) (range) age was ۳۹.۴ (۲۲.۴) (۲–۷۴) years, and most patients were female. The most common secondary cause was previous vitreoretinal surgery with silicone oil tamponade (۱۵.۶%); however, idiopathic cases were the most common (۱۸.۸%). Systemic comorbidities were present in ۲۷.۶% of patients, consisting of hypertension, diabetes mellitus, epilepsy, coronary artery disease, Behcet’s disease, and juvenile idiopathic arthritis; however, none of the patients had systemic diseases associated with hypercalcemia. Two of the ۳ patients with bilateral involvement had chronic uveitis secondary to systemic rheumatological disease. The mean (SD) follow-up duration was ۵.۶ (۴.۰) years, and no serious postoperative complications occurred. The mean (SD) baseline and final BCDVA in logarithm of the minimum angle of resolution (logMAR) were ۱.۹۸ (۱.۰) and ۱.۷ (۱.۰), respectively (P > ۰.۰۵). Combined EDTA chelation and superficial keratectomy with and without AMT were performed in ۱۲.۵% and ۸۷.۵% of eyes, respectively. Recurrence was observed in ۳۷.۵% of eyes within the mean (SD) (range) follow-up of ۹.۴ (۹.۱) (۱–۳۲) months. Seven of the ۱۲ eyes with recurrence underwent re-EDTA chelation combined with superficial keratectomy and AMT; however, ۵ patients managed conservatively. Conclusions: In this study, band keratopathy requiring intervention more commonly affected female individuals and was unilateral. Most cases were idiopathic. Systemic comorbidities were present in approximately one-third of cases. Managing band keratopathy using a combination of EDTA chelation and superficial keratectomy with or without AMT could be a potential treatment modality. Further large-scale studies are required to provide robust conclusions regarding the efficacy and safety of this management approach. Keywords: band keratopathy corneal degeneration ethylenedinitrilotetraacetic acid chelation therapies keratectomies amniotic membrane visual acuities recurrences