Utilizing Sertoli Cell Transplantation as a Therapeutic Technique for the Management of Neurodegenerative Diseases
محل انتشار: مجله آرشیو رازی، دوره: 79، شماره: 4
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 85
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ARCHRAZI-79-4_004
تاریخ نمایه سازی: 15 شهریور 1403
چکیده مقاله:
Neurodegenerative diseases (NDs) such as, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are defined by aberrant protein accumulation, brain atrophy, and gradual decline of neuronal function. Despite the considerable endeavors devoted to discovering treatments for NDs in recent decades, the demand for efficient therapeutic agents persists. Sertoli cells (SCs) play a crucial role in providing a supportive structure and environment for the development of germ cells. SCs, whether transplanted as xenogeneic or allogeneic cells, present a viable choice for enhancing graft persistence via the release of immunomodulatory and trophic factors, including neurturin (NTN), platelet-derived growth factor, Fas (CD۹۵) ligand (FasL), glial-derived neurotrophic factor, interleukin ۱ (IL۱), brain-derived neurotrophic factor, interleukin ۶ (IL۶), transforming growth factors, and vascular growth factor, that protect replaced cells and tissues from the immune system. However, there is currently no cohesive evidence regarding the neuroprotective influence of SCs transplantation on NDs. Therefore, the focus of this review is to assess the neuroprotective impact of stem cells on neurodegenerative diseases in preclinical settings and present cohesive information. A comprehensive search was conducted between ۲۰۰۰ and ۲۰۲۲ in Medline, Scopus, and the Web of Science. In the identification stage, after a comprehensive search across databases including Web of Science, Scopus, and PubMed/Medline, ۱۰۳ papers were obtained. Our search yielded a total of nine relevant papers on the therapeutic effect of SCs transplantation on NDs. It was found that SCs transplantation exhibits a promising impact on enhancing neurological diseases' symptoms in rats. Our findings highlight the need for multiple standardized preclinical trials to be performed to find reliable information to confirm the utilization of SCs transplantation and the reduction of neurodegenerative disease symptoms.
کلیدواژه ها:
نویسندگان
Hosyin Ahmady
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mahsa Afrand
Roya Physiotherapy Clinic, Tehran, Iran
Monireh Motaqi
Physiotherapy Research Center, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Gholam Hossein Meftahi
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :