Efficacy of Aqueous Extract of Allium sativum and Tamsulosin Comparison on Reducing Pain and Expulsion of Kidney and Ureter Stones in Adult Patients

Aims: Due to the widespread use of Allium sativum or garlic for food and medical purposes as well as the diuretic, analgesic, anti-inflammatory, and antispasmodic effects of garlic and its extract in various diseases, this study aimed to compare the effect of aqueous extract of Allium sativum and tamsulosin on reducing pain and expulsion of kidney and ureter stones in adult patients. Materials & Methods: In this clinical trial study, ۸۰ patients older than ۱۸ with kidney and ureteral stones less than ۱۰mm were randomly assigned to one of the two groups, including tamsulosin as a control group and intervention group (Allium sativum or garlic). A tamsulosin capsule was administered one capsule every night for two weeks in the first group. In the second group, Allium sativum was prescribed in a dose of ۹۰۰ mg per day in tree-divided capsules with a glass of water for two weeks. Two weeks later, patients were visited, KUB or sonography was performed, and the amount of stone change and the presence of residual stones were measured and recorded. The patient's pain level was checked using a visual analog scale, and data were collected during treatment and at the end of the study. All data were analyzed using SPSS software version ۲۱. Findings: The mean age of patients in the control and intervention groups were ۴۸.۴۴±۱۴.۶۵ and ۴۴.۱۸±۱۲.۹۰ years, respectively (p=۰.۸۲). The size of stones after treatment in the intervention and control groups were ۸.۰۵±۳.۷۹ and ۶.۷۶±۲.۵۱mm, respectively (p=۰.۱۴۲). The mean pain intensity based on visual pain criteria before treatment was not significantly different in the two groups (p=۰.۴۳۸). Still, after treatment, the pain level in the intervention group compared to the control group significantly decreased (p=۰.۰۰۱). Conclusion: The results showed that the size and expulsion of stones treatment were not significantly different between the two groups. Still, the severity of pain in the Allium sativum group was significantly reduced compared to the control group. It can be used as an adjunct therapy to control pain and help the passage of stones.

کلیدواژه ها:

Urinary Stones ، Medical Therapy ، Tamsulosin ، Allium sativum