Effect of Rosa damascene Mill. Hydroalcoholic Extract on the Treatment of Chronic Idiopathic Constipation in Adults

Aims: Constipation is an important problem and dysfunction of the digestive system. In the traditional beliefs of different parts of the world, especially Iran, Rosa damascene Mill. has several properties, including sedative, anti-inflammatory, anti-seizure, anti-depressant, and laxative effects. This study aimed to evaluate the effect of hydroalcoholic extract of Rosa damascene Mill. in treating chronic constipation in adults. Materials & Methods: This randomized clinical trial was performed in ۲۰۱۸ in Shahid Mofteh Specialized Clinic of Yasouj on ۱۶۰ patients with chronic constipation referred to internal medicine and gastroenterologists. Extracted hydroalcoholic extract of Rosa damascene Mill. and lactulose syrup was used; The control group received ۲۰cc of lactulose syrup twice a day, and the intervention group received a hydroalcoholic extract of Rosa damascene Mill. two times a day in the form of ۵۰۰mg capsules twice a day for one month. Data were analyzed using SPSS ۱۹ software and T and chi-square tests with ۹۵% confidence interval. Findings: During the intervention process, ۱۶ people did not refer to the necessary follow-up, and the necessary information was collected from ۱۴۴ patients with chronic constipation. Sixty-eight patients (۴.۲%) were male, and ۷۶ (۵۲.۸%) were female. The mean age of patients was ۴۳.۱۸±۱۳.۶۷, and the age range was ۱۸ to ۷۵ years. There was no statistically significant difference between the two groups' mean age and sex under Rosa damascene Mill.'s intervention. Hydroalcoholic extract and lactulose (p<۰.۰۵). Also, there was no statistically significant difference between the variables of frequency and ease of defecation between the two groups receiving lactulose and Rosa damascene Mill. hydroalcoholic extract before and after the intervention (p<۰.۰۵). Conclusion: Hydroalcoholic extract of Rosa damascene Mill. has a similar effect to lactulose in the treatment of chronic constipation in adults.

کلیدواژه ها:

Chronic Constipation ، Hydroalcoholic Extract of Rosa damascene Mill ، Lactulose