Changes in Lipid Profiles, Insulin Resistance and Serum Fibroblast Growth Factor ۲۱ Following Three Types of Exercise Training in Obese Children

Aims: Obesity and immobility predispose to cardiovascular disease. Today, changing childhood lifestyle may affect cardiovascular disease factors. This research aimed to determine the effect of three types of exercise training, including endurance exercise, resistance exercise, and combined exercise, on lipid profiles, insulin resistance, and serum FGF۲۱ in obese children. Materials & Methods: This experimental study was conducted on a total of ۸-۱۲ years old male students of elementary schools in Yasuj, Iran (N=۱۸۰۳۸) in October ۲۰۰۶. Sixty obese students, by the simple and voluntarily sampling method, were randomly allocated four groups (۱۵ individuals): Resistance exercise, endurance exercise, and combined exercise, and control. Blood sampling was taken ۲۴ hours before the start of the training period and ۴۸ hours after the end latest session of the training period at the Laboratory of Shahid Beheshti Hospital in Yasuj, and the factors such as Glucose, TC, TG, LDL, VLDL, HDL, VO۲max, HOMA-Insulin Resistance, and Serum FGF-۲۱ were measured. Data were analyzed by SPSS ۲۱ software using the ANCOVA test. Findings: Their BMI and VO۲max were ۳۲.۳۶±۲.۳۱kg/m۲ and ۲۳.۰۶±۱.۷۲ lit/kg/min, respectively, which showed that subjects were non-active (sedentary) obese in pre-training. Results showed that eight weeks of EE, RE, and CE had a significant effect on increasing serum HDL (F=۳.۰۴; p<۰.۰۰۱) and on decreasing of glucose (F=۲.۹۸; p<۰.۰۰۱), TC (F=۴.۳۳; p<۰.۰۰۱), TG (F=۵.۴۴; p<۰.۰۰۱), LDL (F=۴.۸۶; p<۰.۰۰۱), VLDL (F=۵.۵۸; p<۰.۰۰۱). There was a significant difference between the training intervention groups in pre-training and post-training in the HOMA-Insulin Resistance variable (F=۳.۲۸; p<۰.۰۰۱), which had decreased, and serum FGF-۲۱ (F=۲.۴۵; p<۰.۰۰۱) which had increased. Also, results illustrated that the EE method was better than RE and CE in improving these variables. Conclusion: Applied training methods in this study, especially endurance exercise, can be considered suitable interventions to reduce cardiovascular risk factors related to obesity in childhood.

کلیدواژه ها:

Exercise ، Insulin resistance ، Fibroblast Growth Factor ۲۱ ، Lipid