Administration of mesenchymal stem cells in reducing the progression ofParkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by severedyskinesia due to the progressive loss of dopaminergic neurons along the nigrostriatal pathway. The currentfocus of treatment is palliation of symptoms through administration of levodopa, such as L-۳,۴-dihydroxyphenylalanine replacement therapy, administration of dopaminergic agonists, functionalneurosurgery, and gene therapy, rather than prevention of dopaminergic neuronal damage. Hence, theapplication and development of neuroprotective/disease-protective strategies is absolutely necessary.Currently, stem cell therapy is considered for the treatment of PD. As for stem cells, mesenchymal stem cells(MSCs) seem to be the most promising. In this review, we analyzed the mechanisms of action of MSCs inParkinson's disease. The results of the studies indicated that Mesenchymal stem cells show immunomodulatingeffects after penetrating the injury sites, so that they can reduce inflammation and heal the tissue and MSCprevents the progression of the disease by reducing the damage of the remaining cells, and on the other hand,it causes recovery by changing the nerve cells.

کلیدواژه ها:

Parkinson ، cell therapy ، Mesenchymal stem cells